Assessment of Fundamental Clinical Sciences for Osteopathic Medical Practice

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Please note that the COMLEX-USA Level 2-CE examination does not include any COVID-19 questions at this time due to the rapidly changing nature of the information.

Examination Description

COMLEX-USA Level 2-Cognitive Evaluation (CE) is a one-day computer-based assessment that integrates application of knowledge in clinical science and foundational biomedical sciences and osteopathic principles with other physician competencies related to the clinical care of patients and promoting health in supervised clinical settings. Competency domains assessed include application of osteopathic medical knowledge, osteopathic patient care and osteopathic principles and practice, communication, systems-based practice, practice-based learning and improvement, professionalism and ethics.

COMLEX-USA Level 2-CE · Clinical Sciences Disciplines

The examination consists of two computer-based test sessions of four hours each taken on one day in a secure, time-measured environment. It contains 352 test questions related to diverse clinical and patient presentations and seven defined competency domains for osteopathic medical practice. Test questions are single best answer multiple choice format with some novel test items involving audio-visual components designed to assess an expanded physician competency subset. Examples of test item types expected to be encountered in Level 2-CE can be found under Practice Exams.


Passing COMLEX-USA Level 2-CE indicates that the candidate has demonstrated competence in the clinical sciences and osteopathic principles and related physician competency domains for osteopathic medical care of patients as required to enter into supervised graduate medical education settings and to continue lifelong learning.

Road to DO Licensure

A whole new program for osteopathic medical students and residents.