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Assessment of Fundamental Clinical Sciences for Osteopathic Medical Practice

Eligibility Blueprint Examination Format Registration Examination Dates
Test Accommodations Examination Day Practice & Preparation Scoring & Reporting

The NBOME will transition administration of COMLEX to Pearson VUE beginning with Level 3 in January 2023. Click here to learn more.

Please note that the COMLEX-USA Level 2-CE examination does not include any COVID-19 questions at this time due to the rapidly changing nature of the information.

Examination Description

COMLEX-USA Level 2, administered in a time-measured environment that integrates the foundational biomedical sciences with other areas of medical knowledge relevant to solving clinical problems and promoting and maintaining health during the provision of osteopathic medical care to patients. Competency domains assessed include application of osteopathic medical knowledge, osteopathic patient care and osteopathic principles and practice, communication, professionalism and ethics. Competency assessment occurs in the context of clinical and patient presentations and systems-based practice, as required for entry into the supervised practice of general osteopathic medicine, and for readiness in lifelong learning, practice-based learning, and improvement.

COMLEX-USA Level 2-CE · Clinical Sciences Disciplines

The examination consists of two computer-based test sessions of four hours each taken on one day in a secure, time-measured environment. It contains 352 test questions related to diverse clinical and patient presentations and seven defined competency domains for osteopathic medical practice. Test questions are single-best-answer multiple-choice format with some novel test items involving audio-visual components designed to assess an expanded physician competency subset. Examples of test item types expected to be encountered in Level 2-CE can be found under Practice Exams.


Passing COMLEX-USA Level 2-CE indicates that the candidate has demonstrated competence in the clinical sciences and osteopathic principles and related physician competency domains for osteopathic medical care of patients as required to enter supervised patient care settings and to continue lifelong learning.

Road to DO Licensure

A whole new program for osteopathic medical students and residents.